4 edition of The involvement of substance P in relapse to cocaine-seeking behaviour in rats found in the catalog.
The involvement of substance P in relapse to cocaine-seeking behaviour in rats
Franca M. Placenza
Thesis (M.Sc.) -- University of Toronto, 2001.
|Series||Canadian theses = -- Thèses canadiennes|
|The Physical Object|
|Pagination||1 microfiche : negative. --|
The purpose of this grant is to combine a novel behavioral paradigm and advanced molecular, neurochemical, neuropharmacological, neuroanatomical as well as pharmacogenetic techniques to determine brain mechanisms that actively suppress 'addiction-like' cocaine seeking in rats. An experimental drug that lowers norepinephrine levels can inhibit relapse-like behaviors in rats trained to give themselves cocaine. In the new paper, research assistant professor Jason Schroeder, (first author of the paper) conducted experiments where rats are trained to press a lever to get a drug infusion.
and relapse are amenable to modeling in animals. Rats and mice readily self-administer the same psychoactive drugs as humans including co-caine, and following a period of abstinence, reinstate their drug seeking when exposed to the same factors that put humans at risk of relapse— “priming” doses of the drug, stress, and drug-associated cues. We focus here on cue-induced reinstatement of cocaine seeking, because this not only models key aspects of relapse in human addicts, but also reveals the involvement of limbic cortical–ventral striatopallidal systems (Fig. 1) in cocaine addiction. A basic feature of this procedure is that established drug taking is first extinguished and then.
Neurobiology of Relapse to Heroin and Cocaine Seeking. of Share & Embed. The molecules that make cocaine addicts more likely to relapse when experiencing stress have been identified. The researchers involved in the study believe they may have found a target for future.
Recycled asphalt earing courses
Montreal condensed reports
Catalogus librorum theologicorum, juridicorum, philologicorum, medicorum, &c bibliothecae... Benj. Broeckhuysen... &aliorum
The camel hunt
uniform consumer credit code
beginners Chinese-English dictionary of the national language (Gwoyeu)
Commodity prices from the Ramessid period
Business Outlook 1978.
co-composting of domestic solid and human wastes
Law and the Internet
Current Issues and Enduring Questions 7e & Working with Sources
Education: its evolutionary rhythm.
Three physico-theological discourses ...
Excellent progress has come from research on the brain circuits underlying the reinstatement of cocaine seeking in experimental animals, typically rats (for review, see Kalivas & McFarland, ). In this report, we describe the reinstatement model and what it has revealed about the role of prefrontal cortex (PFC) in relapse to cocaine by: Cocaine-injected rats and mice treated with acamprosate showed attenuated relapse-like behavior such as reduced drug and cue-induced reinstatement of cocaine-seeking behavior (Bowers et al., ; Mcgeehan & Olive, ), as well as a reduction in the development of conditioned place preference (Mcgeehan & Olive, ).
The present study was designed to evaluate the role of D2-like receptor activation in drug-seeking behavior in detail, i.e.: i) by comparing reinstatement of heroin- and cocaine-seeking at Cited by: The conditioning of the pharmacological actions of cocaine with environmental stimuli is thought to be a critical factor in the long-term addictive potential of this drug.
Cocaine-related stimuli may increase the likelihood of relapse by evoking drug craving, and brain-imaging studies have identified the amygdala and nucleus accumbens (NAcc) as putative neuroanatomical substrates for these Cited by: Long-lasting vulnerability to drug cue-induced relapse to a drug-taking habit is a major challenge to the treatment of drug addiction.
Here we show that blockade of drug memory reconsolidation, through infusion of Zif antisense oligodeoxynucleotides into the basolateral amygdala shortly before reexposure to a cocaine-associated stimulus but not simply to the training context, Cited by: Consistent with this idea, several studies have demonstrated the involvement of the OFC in cocaine seeking or relapse after re-exposure to cocaine-related cues in both humans and laboratory.
The Involvement of Oxytocin in the Subthalamic Nucleus on Relapse to Methamphetamine-Seeking Behaviour Article (PDF Available) in PLoS ONE 10(8):e August with 70 Reads.
Since substance P and NK1 receptors are co-localized with central CRH and CRH receptors, substance P likely interacts with CRH systems in mediating stress activated relapse.
Arginine vasopressin (AVP) is a neuroactive peptide that activates multiple stress systems, including the HPA axis and elements of the extended amygdala, and modulates. University of Washington, Department of Psychiatry & Behavioral Sciences, Grand Rounds.
Sunila Nair, M.D., “Relapse to cocaine seeking: Behavioral and. The phenotype of D 3 R-expressing neurons has been examined in double in-situ hybridisation studies, and a high proportion of GABAergic medium spiny neurons in the shell of nucleus accumbens was found to express D 1 R, D 3 R and substance P mRNA (figure 1, table I).Co-stimulation of the two dopamine receptor subtypes in vivo results in a synergistic interaction: whereas a D 1 R.
Apr. 11, — Even a single, brief stress can induce days of relapse to cocaine-seeking among rats, but a new study shows how the tendency to relapse. Here, we extended this procedure to relapse to cocaine seeking after punishment-imposed abstinence. Methods: We trained rats to self-administer cocaine ( mg/kg/infusion, 6-h/d) in context A under continuous reinforcement and s variable interval (VI30) reinforcement schedules (6 d.
The two photographs show the neurons in the rats trained to associate a cue with cocaine. The upper image shows the spine heads of the neurons before the rats experienced a cue-induced relapse to cocaine-seeking and the lower image the spine heads 15 minutes after the induced relapse.
Subjects. Male Long-Evans (Charles River, Raleigh, NC) rats (– g) were housed individually in a climate-controlled animal colony (lights on from 8 P.M.
to 8 A.M.) with food and water. Abstract. The most insidious aspect of drug addiction in humans is a high and recurrent propensity to relapse. Over the past several decades, the reinstatement procedure has received widespread use as an animal model of drug relapse, to study the basic mechanisms underlying drug-seeking responses in laboratory animals.
Even a single, brief stress can induce days of relapse to cocaine-seeking among rats, but a new study shows how the tendency to relapse persists and how to shut it down, suggesting a new pathway. Rats were tested for context relapse, followed by daily extinction and subsequent reinstatement testing.
(B) Active lever presses during the last 3 days of self-administration. (C) Relapse to meth-seeking in the meth context after abstinence (*p. SR, a compound that blocks rats' CB-1 receptors, dramatically reduced resumption of cocaine-seeking responses triggered by two of the three most common triggers of relapse in humans: a priming dose of cocaine and environmental cues associated with cocaine reward.
The compound did not reduce cocaine-seeking triggered by stress. Recent findings on the effects of cocaine on the brain show that the drug causes major changes that influence the risk of relapse under stress. Summary: Disrupting memories associated with environmental cues significantly reduces cocaine seeking behaviors in rat models of addiction, a new study reports.
Source: University of Pittsburgh. Forty to 60 percent of all people treated for substance use disorders relapse, presenting a major challenge to treatment success.
New research from the University. Impulsive rats also show increased motivation to take drug using a progressive ratio and would persist longer with cocaine seeking even when paired with a foot shock, indicating compulsivity (Belin et al.
). They also showed greater relapse to cocaine seeking after punishment‐induced abstinence (Economidou et al.
).Hyytia P, Koob GF () GABAA receptor antagonism in the extended amygdala decreases ethanol self administration in rats. Eur J Pharmacol – PubMed CrossRef Google Scholar Lê AD, Harding S, Juzytsch W, Funk D, Shaham Y () Role of alpha-2 adrenoceptors in stress-induced reinstatement of alcohol seeking and alcohol self.cance is the role of stress in inducing relapse to cocaine-seeking, as cocaine use is known to induce plastic changes to the respon-siveness of the body’s primary stress responsive system, the HPA axis, and these alterations will be discussed elsewhere.
However, stress-induced relapse is hallmark of virtually all drugs of abuse as.